Pilot study on the pharmokinetics of p-phenylenediamine and its metabolites after application to the skin by means of Raman spectroscopy.

Pilot study on the pharmokinetics of p-phenylenediamine and its metabolites after application to the skin by means of Raman spectroscopy. - Pilot study on pharmacokinetics of PPD by Raman spectroscopy.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36061

Enrollment

Registered

2011-08-17

Start date

2011-11-24

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Farmacokinetiek van de stof p-fenyleendiamine na applicatie op de huid. allergic contact dermatitis eczema

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: adulthood legal competence

Exclusion criteria

Exclusion criteria: History of allergic contact dermatitis to PPD Active eczema or skin disease on the lower-arm (volar side). Legally incompetence Pregnancy

Design outcomes

Primary

Measure	Time frame
Experiment 1 1a: Determination of PPD penetration as a function of applicationtime and clearance. 1b: Determination of PPD penetration in the epidermis and dermis as a function of applicationtime and clearance. Experiment 2: Determination of the formation of PPD-metabolites MAPPD, DAPPD and BB after topical application of PPD.	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results