Dyspnoea in Pulmonary Arterial Hypertension: Targeting the Diaphragm muscle

Dyspnoea in Pulmonary Arterial Hypertension: Targeting the Diaphragm muscle - Diaphragm dysfunction in PAH

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36056

Enrollment

Registered

2011-07-29

Start date

2011-07-19

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aandoeningen van de ademhalingsspieren Pulmonary arterial hypertension diaphragm dysfunction

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients with chronic thromboembolic pulmonary hypertension scheduled for a pulmonary thrombo endarterectomy. - Age: > 18 years - Gender: Both male and female - all ethnic backgrounds

Exclusion criteria

Exclusion criteria: - COPD (GOLD stage II-IV) and CHF (NYHA class III-IV) - Neuromuscular disease - chronic use of corticosteroids (defined as >7.5 mg/day for at least 3 months) - >10% weight loss within last 6 months

Design outcomes

Primary

Measure	Time frame
Main study parameter/endpoint: Contractile force and structure of single diaphragm muscle fibers	—

Secondary

Measure	Time frame
Secondary study parameters/endpoints: * Morphological determination of muscle fiber cross sectional area * Muscle fiber ultrastructure by electronmicrocopy * Posttranslational modification of contractile proteins * Diaphragm cytokine profile * Gene expression analysis by Affymetrix * Comparison of findings from diaphragm muscle to those from the non-respiratory pectoralils major muscle * Correlation between diaphragm muscle fiber strength and pulmonary function	—

Measure

Time frame

Secondary study parameters/endpoints: * Morphological determination of muscle fiber cross sectional area * Muscle fiber ultrastructure by electronmicrocopy * Posttranslational modification of contractile proteins * Diaphragm cytokine profile * Gene expression analysis by Affymetrix * Comparison of findings from diaphragm muscle to those from the non-respiratory pectoralils major muscle * Correlation between diaphragm muscle fiber strength and pulmonary function

—

Countries

Netherlands

Outcome results