Pathological gambling
Conditions
Interventions
Each subject will receive a placebo and 400mg sulpiride on separate testing
days.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All groups: males volunteers between 18 and 55 years of age, predominant right-handedness Pathological gambling group: *active* pathological gamblers, as assessed by a score >= 5 on the SOGS questionnaire and the presence of 5 or more DSM-IV criteria for the diagnosis of pathological gambling Control group: score
Exclusion criteria
Exclusion criteria: - neurological disorders - DSM-IV axis I psychiatric disorders other than pathological gambling / nicotine dependence - current psychiatric treatment - heart problems - claustrophobia - metallic implants (See p. 14 on the research protocol for more details)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Blood Oxygenation Level Dependent (BOLD) signal as measured with functional magnetic resonance imaging (fMRI) - Behavioral performance on computerized tasks - Psychophysiological recordings, e.g., electrodermal activity, blood pressure, heart rate and eye tracking | — |
Secondary
| Measure | Time frame |
|---|---|
| - Subjective measurements ,e.g., self-report questionnaires, visual analogue scales - Blood plasma levels of prolactin and sulpiride | — |
Countries
Netherlands
Outcome results
None listed