Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? A cross-over clinical trial

Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? A cross-over clinical trial - Periodontitis-RA, cross-over clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON36017

Enrollment

Registered

2011-06-24

Start date

2011-07-15

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gum disease periodontal disease

Interventions

Non-surgical periodontal treatment and systemic antimicrobials.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: RA patients 1. Fulfilling the American College of Rheumatology classification criteria for RA (1987) 2. Age > 18 years 3. Fulfilling the classification criteria of periodontal diseases for generalized severe chronic periodontitis according to the 1999 International Workshop for Classification of Periodontal Diseases and Conditions

Exclusion criteria

Exclusion criteria: 1. Infection or inflammation other than periodontitis or RA 2 Present malignancy 3. Other conditions which influence the immune system:, diabetes, active thyroid disease, myocardial infarction, stroke or recanalisation of the femoral arteries for claudication 10mg/dag, antibiotic use during 3 months prior to the study, allergy to amoxicillin or metronidazole 8. Edentulism

Design outcomes

Primary

Measure	Time frame
Disease Activity Score 28 joint count (DAS28)	—

Secondary

Measure	Time frame
Periodontal Inflamed Surface Area (PISA) ACPA titer Leucocyte count, CRP and ESR. Presence of P. gingivalis in microbial plaque	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)