Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? An observational study.

Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? An observational study. - Periodontitis-RA, observational study.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36011

Enrollment

Registered

2011-06-24

Start date

2011-07-15

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gum disease Periodontal disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Study group: RA patients 1. Fulfilling the American College of Rheumatology classification criteria for RA (1987). 2. Age > 18 years. Control group: individuals without RA, aged >18 years.

Exclusion criteria

Exclusion criteria: According to the SENIEUR protocol (1984): 1. Infection or inflammation other than periodontitis or RA. 2. Present malignancy. 3. Other conditions which influence the immune system: diabetes, active thyroid disease, myocardial infarction, stroke or recanalisation of the femoral arteries for claudication 10mg/dag, antibiotic use during 3 months prior to the study. 8. Edentulism.

Design outcomes

Primary

Measure	Time frame
The Dutch Periodontal Screenig Index (DPSI) (van der Velden 2009).	—

Secondary

Measure	Time frame
Disease Activity Score 28 joint count (DAS28) Eastman Interdental Bleeding Index (EIB, Caton&Polson 1985) Visible plaque index (VPI, Ainamo&Bay 1975) ACPA titer Anti-Pg titer Presence of Porphyromonas gingivalis Presence of ACPAs in gingivocrevicular (GCF) Presence of HLA DR/DQ Leucocyte count, ESR, CRP	—

Countries

Netherlands

Outcome results