Subarachnoid hemorrhage
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subarachnoid hemorrhage with aneurysmal pattern on CT or xanthochromia of the cerebrospinal fluid and aneurysm demonstrated on angiography
Exclusion criteria
Exclusion criteria: Any chronic inflammatory condition Perimesencephalic hemorrhage Pattern of hemorrhage on CT not compatible with ruptured aneurysm Body weight
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate whether the endothelial glycocalyx is affected after SAH and in DCI and is related to severity of SAH. Differences in glycocalyx volume will be assessed by Sideview Darkfield (SDF) imaging as estimate of glycocalyx volume in patients with SAH and by measurement of glycocalyx constituents in plasma. DCI is diagnosed clinically, excluding other causes of neurologic deterioration. Severity of SAH is defined by the WFNS score. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Association between gylocalyx volume and administration MgSO4 in SAH - Association between glycocalyx perturbation in SAH and vasomotion changes as non-invasively assessed by finger arterial waveform registration. - Association between glycocalyx perturbation and blood pressure - Association between glycocalyx perturbation and clinical outcome, defined by the Rankin scale 3 months after the SAH. The Rankin scale is a 6-point handicap scale that focuses on restrictions in lifestyle. - Association between glycocalyx perturbation and endothelial damage, platelet activation, thrombin generation and fibrinolytic activity | — |
Countries
Netherlands
Outcome results
None listed