Molecular studies in a multigenerational family with gastro-esophageal reflux disease (GERD)

Molecular studies in a multigenerational family with gastro-esophageal reflux disease (GERD) - Molecular studies in a family with GERD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35981

Enrollment

Registered

2012-01-17

Start date

2012-02-05

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

GERD heartburn

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Affected family members and all adult unaffected family members will be asked to participate. Family members are considered to be affected either if a diagnosis of GERD has been made by a physician (usually a [pediatric] gastroenterologist), if additional investigations such as pH/impedance measurements or gastroesophageal endoscopies show evidence for GERD, or if anti-reflux surgery has been performed in the past. GERD is considered as a dichotomous trait in this study. - Informed consent is needed to be included. Informed consent will be asked for by the parents when children are under the age of 12 years. At present there is only a single affected child (8 yrs) in this family.

Exclusion criteria

Exclusion criteria: Insufficient understanding of the purpose and risks of the study.

Design outcomes

Primary

Measure	Time frame
The primary outcome is linkage to one or more chromosome regions and idenfication of associated gene(s) in the GERD family.	—

Secondary

Measure	Time frame
The secondary outcome will consist of a thorough description of the clinical characteristics, the phenotype, of patients with GERD in this family.	—

Countries

Netherlands

Outcome results