The effects of oral administration of lactobacillus plantarum WCFS1, Lactobacillus plantarum CIP104448, and Lactobacillus plantarum CIP104450 on small intestinal mucosa and barrier function

The effects of oral administration of lactobacillus plantarum WCFS1, Lactobacillus plantarum CIP104448, and Lactobacillus plantarum CIP104450 on small intestinal mucosa and barrier function - oral probiotics

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON35954

Enrollment

Registered

2011-07-25

Start date

2011-10-11

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastrointestinal discomfort irritable bowel syndrome

Interventions

Food supplements (probiotics) for 4 periods of 1 week each, sugar tests with subsequent urine collection, gastroduodenoscopy (intestinal investigation)

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: no gastrointestinal complaints age between 18 and 65 yrs BMI between 20 and 30 kg/m2

Exclusion criteria

Exclusion criteria: medication, except oral contraceptives major abdominal surgery interfering with gastrointestinal function in the 180 days prior to study smoking

Design outcomes

Primary

Measure	Time frame
1. Effects on immune modulation. Measurement of IL-10 and IL-12 production 2. Effect on intestinal epithelial permeability.	—

Secondary

Measure	Time frame
1. Effects on epithelial gene regulation, tight junction modulation 2. Effects on peripheral markers of immune regulation, immune parameters	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)