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The role of genetics in the pathophysiology of gastro-oesophageal reflux disease.

The role of genetics in the pathophysiology of gastro-oesophageal reflux disease. - Genetics in GORD

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON35951
Enrollment
500
Registered
2012-01-26
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastro-oesophageal reflux disease reflux disease

Interventions

None listed

Sponsors

Academisch Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patient inclusion criteria: -Subjects undergoing a 24-hour esophageal pH-measurement with the indication heartburn/reflux. -Subjects undergoing a control upper endoscopy for reflux oesophagitis. -Written informed consent -Age >18

Exclusion criteria

Exclusion criteria: History of disease/surgery affecting gastrointestinal motility

Design outcomes

Primary

MeasureTime frame
The information obtained will contain all coding regions (exones) of each participant. Not all variants in all exones will be evaluated: the results in patients will be compared to one another in order to find variants in genes they have in common.—

Secondary

MeasureTime frame
Severity and frequency of reflux symptoms Quality of Life—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)