Brain research in Whiplash Associated Disorder

Brain research in Whiplash Associated Disorder - BRIWAD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35947

Enrollment

Registered

2011-07-08

Start date

2012-01-18

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

whiplash

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Females, between 18 and 45 years. Right-handed Body Mass Index equal/less than 29 For patients: Rear end automobile collision Whiplash Associated Disorder (WAD) classified as grade I or II At least 2 years from the accident, up to 10 years. No treatment for WAD other than painkillers

Exclusion criteria

Exclusion criteria: Pregnant or in menopause. Use of anticoagulants, medication that affect the immune system or investigation drug. Current or recent alcohol or substance abuse. Current or recent infectious, inflammatory, metabolic or systemic disease. Impossibility to perform a PET scan (claustrophobia...) Diagnosis of Depression or Anxiety.

Design outcomes

Primary

Measure	Time frame
The primary objective is to compare regional cerebral blood flow (rCBF) in response to non-painful neck stimulus, between patients with WAD and healthy matched control volunteers, ascertained by Positron Emission Tomography (PET) scan. Each subject will be exposed to four different conditions: rest state, placebo-like stimuli, low intensity stimuli, and high intensity neck stimuli. The rCBF corresponding to exposure to each stimulus is measured in the brain by PET.	—

Measure

Time frame

The primary objective is to compare regional cerebral blood flow (rCBF) in response to non-painful neck stimulus, between patients with WAD and healthy matched control volunteers, ascertained by Positron Emission Tomography (PET) scan. Each subject will be exposed to four different conditions: rest state, placebo-like stimuli, low intensity stimuli, and high intensity neck stimuli. The rCBF corresponding to exposure to each stimulus is measured in the brain by PET.

—

Secondary

Measure	Time frame
The secondary objective is to determine if there is a correlation between rCBF response and the results in the questionnaires.	—

Countries

Netherlands

Outcome results