metabole flexibiliteit ability to adapt changes in metabolic processes in the human body
Conditions
Interventions
Ten subjects (group 1) will receive a high-fat high-caloric diet for four
weeks. The high-fat high-caloric diet consists of a daily overload of fat and
calorie-rich foodstuffs, accounting for approx
Sponsors
TNO
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group 1: 1. Healthy as assessed by the - health and lifestyle questionnaire, (P9218 F02; in Dutch) - results of the pre-study laboratory tests 2. Males aged > 35 and 23 and 35 and 23 and
Exclusion criteria
Exclusion criteria: Group 1: 1. Participation in any clinical trial including blood sampling and/or administration of substances up to 90 days before Day 01 of this study 2. Participation in any non-invasive clinical trial up to 30 days before Day 01 of this study, including no blood sampling and/or oral, intravenous, inhalatory administration of substances 3. Having a history of medical or surgical events that may significantly affect the study outcome (including (medication for) diabetes, cholesterol lowering medication, eating disorders and/or food allergy (f.i. allergic to cow milk or (pea)nuts). 4. Smoking. 5. Alcohol consumption > 28 units/week for males. 6. Exercise more than 3 hours/week. 7. Reported unexplained weight loss or gain of > 2 kg in the month prior to the pre-study screening 8. Reported slimming or medically prescribed diet 9. Reported vegan, vegetarian or macrobiotic 10. Recent blood donation ( 28 units/week for males. 6. Exercise more than 3 hours/week. 7. Reported unexplained weight loss or gain of > 2 kg in the month prior to the pre-study screening 8. Reported slimming or medically prescribed diet 9. Reported vegan, vegetarian or macrobiotic 10. Recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study endpoint is the integrated response of the subjects to the acute oral fat load. | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed