The three hit hypothesis of psychopathology revisited in a human model exposed to transient endogenous glucocorticoids excess: patients treated for Cushing's syndrome

The three hit hypothesis of psychopathology revisited in a human model exposed to transient endogenous glucocorticoids excess: patients treated for Cushing's syndrome - The three hit hypothesis of psychopathology in Cushing's syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35930

Enrollment

150

Registered

2011-06-23

Start date

2011-08-01

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cushing's syndrome Hypercortisolism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - men and women between 18 and 70 years of age - patients treated for Cushing's syndrome - adequately substituted - patients should be prepared and well informed about the study - patients should sign the informed consent

Exclusion criteria

Exclusion criteria: - difficulty to understand the Dutch language - insufficient clinical data - head trauma or CVA - dementia - alcohol or drugs abuse

Design outcomes

Primary

Measure	Time frame
1. What are the persistent effects of a transient excess of cortisol in treated Cushing patients? 2. Can we validate the three hit hypothesis of psychopathology in treated Cushing patients in order to distinguish the vulnerable from the resilient individuals for persistent psychopathology in the aftermath of CS?	—

Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results