borderline borderline personality disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age over 18. • Group 1: Patients meeting the DSM-IV criteria for BPD and who are enrolled in the pretreatment group for dialectical behaviour group therapy at the Psychiatry Dept of the RUNMC. • Group 2: Controls, matched for age, gender, and intelligence, not meeting DSM-IV criteria for BPD.
Exclusion criteria
Exclusion criteria: Patients: we do not exclude patient suffering from several *comorbidities*, for instance mood- or eating disorders, because these are more a rule than an exception in BPD . Most important reasons for this are: (i) that the subgroup of patients with BPD formed by excluding the majority of them is not representative for the clinical population; (ii) we are primarily interested in the effectiveness of the therapy over the whole BPD population rather than the efficacy in a certain small subset. Acceptance of this approach in leading literature on BPD can, for example, be seen in the following publication of Silbersweig and colleagues [16]. ;Healthy controls: Psychiatric: • Recurrent Major Depressive disorder or Single Major Depressive disorder within five years. • Other mood- (e.g. bipolar disorder), anxiety- (e.g. social phobic), psychotic- (e.g. delusional disorder, schizophrenia), pervasive devolpmental- (e.g. autistic disorder), attention-deficit- (e.g. ADHD), eating- (e.g. anorexia nervosa) or personality disorders. • (Current) substance abuse or dependence • First degree relatives with DSM IV axis I schizophrenia, or schizophreniform disorder or with bipolar depression, ADHD or BPD. • Mental retardation;Both patients and healthy controls: General exclusion criteria for fMRI: unable to give informed consent, metal implants or splinters, surgical clips, prostheses, artificial heart valves, claustrophobia, electronic equipment in body (such as a pacemaker), pregnancy, and epilepsy.;Psychiatric: • Bipolar disorder, dementia, schizophrenia, delusional disorder, schizophreniform, schizoaffective disorder, shared psychotic disorder, pervasive devolpmental- (e.g. autistic disorder). • Current substance dependence. • First degree relatives with DSM IV axis I schizophrenia, or schizophreniform disorder. • Mental retardation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| During the performance of the tasks we will collect behavioural, psychophysiological (skin conductance and eye tracking) data and functional imaging data. We also collect measures of treatment success (by means of two questionnaires: Outcome Questionnaire and borderline personality disorder severity index). | — |
Secondary
| Measure | Time frame |
|---|---|
| Results will be related not only to measures of severity of BPD, but also to self report measurements of reward and punishment sensitivity, of trait and state anger and anxiety, of impulsivity and of delay discounting. All these measures are thought to have influence either on the instrumental learning phase, Pavlovian conditioning or the PIT phase. | — |
Countries
Netherlands
Outcome results
None listed