middelenafhankelijkheid (heroine) heroin dependence opioid dependence
Conditions
Interventions
Three XRNT injections will be administered at 1-month intervals.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Heroin dependent patients: have a diagnosis of opioid dependence according to DSM-IV criteria. Healthy controls: no diagnosis of substance dependence, no current psychotropic medication. Care will be taken to match controls for gender, age and smoking status.
Exclusion criteria
Exclusion criteria: 1) Age below 18 or over 55 2) Medical contraindications for XRNT or MRI 3) Presence of disorders precluding normal perception of visual and auditory stimuli 4) Patients who are psychiatrically unstable 5) History or evidence of disorders that may affect cerebral function or circulation 6) Female subjects: women who are pregnant or breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain functions of 20 heroin addicts just before and during a three month XRNT treatment using both functional MRI and dopamine transporter SPECT, compared to brain functions of 20 healthy controls. Adverse effects of XRNT on natural rewards. These changes in subjective experiences will be correlated with changes in dopamine transporter density (SPECT). | — |
Secondary
| Measure | Time frame |
|---|---|
| The feasibility and potential efficacy of XRNT in a small sample of 20 heroin addicts in terms of (a) the percentage of patients that actually starts XRNT treatment when invited and (b) the percentage of 3 months retention. Adverse events and side effects will also be measured. | — |
Countries
Netherlands
Outcome results
None listed