leucoderma
Conditions
Interventions
Both the donorsite and recipient site first will be treated with a local
anaesthetic of Lidocain 2% with adrenaline. The punchgrafts will be taken from
the depigmented acceptor region to prepare thi
320*400 nm) facial tanner (HB 171, Philips BV Eindhoven,
the Netherlands) at a power density of 8 mW/cm2. The exposure-time increases
from 4 to 8 to 12 min in the first three sessions. From the four
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Patients with non-segmental and segmental vitiligo under medical treatment at the Netherlands Institute for Pigment Disorders -Age between 18 and 60 years -Patient is willing and able to give written informed consent -Vitiligo stable since 12 months without systemic therapy or 6 months without topical therapy as defined by the absence of new lesions and/or enlargement of existing lesions. -Vitiligo lesions on the extremities or trunk larger than 5x5cm
Exclusion criteria
Exclusion criteria: -UV therapy or systemic immunosuppressive treatment during the last 12 months -Local treatment of vitiligo during the last 6 months -Vitiligo lesions with folliculair or non-folliculair repigmentations -Skin type 1 -Hypertrophic scars -Keloid -Cardial insufficiency -Patients with a history of hypersensitivity to (UVB) light and allergy to local anesthesia. -Patients who are pregnant or breast-feeding -Patients not competent to understand what the procedures involved -Patients with a personal history of melanoma or non-melanoma skin cancer -Patients with a first degree relative with melanoma skin cancer -Patients with atypical nevi.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective assessment of the repigmentation 3 and 6 months after punch grafting. Assessment will be done using a ruler on a dermatoscope to measure the diameter of the growth of the punchgrafts. The surface of repigmentation will be calculated. Visual assessment of side effects (hyperpigmentation, hypopigmentation, scar, cobble stone effect on a scale from 0-3) by a blinded investigator. Number of grafts with repigmentation | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to heal after grafting General outcome assessed by patient. How do you judge the general outcome of the procedure? (Poor, Moderate, Good, Excellent) (at 3 and 6 months) Other assessments: o Photodocumentation: A Canon G6 is used under standardised circumstances (camera setting, distance and flash with polarisation) for photodocumentation. Photographs will be taken before and 3 months after the treatment. o Classification of skin photo type (intake). Skin Photo type Reaction to sun exposure Skin Color I Burn and no tan Pale white II Burn and minimal tan Pale white III Burn and tan well White IV Tan, no burn Light brown V Tan, no burn Brown VI Tan, no burn Dark brown o Duration of the disease (intake) i. 0-6 months ii. 6-12 months iii. 1-5 years iv. 5-10 years v. > 10 years Disease activity (intake): Disease activity VIDA score Active in the past 6 weeks +4 Active in the past 3 months +3 Active in the past 6 months +2 Active in the past year +1 Stable for at least 1 year 0 Stable for at least 1 year and spontaneous repigmentation -1 | — |
Countries
Netherlands
Outcome results
None listed