breastcancer mammary carcinoma
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Women who are of reproductive age (18- 40 yrs), who suffer from estrogen- receptor positive breast cancer and opt for embryo- or oocyte freezing.
Exclusion criteria
Exclusion criteria: 1)Women who are unwilling or unable to sign the informed consent form 2)Women who are not in good enough medical condition to undergo ovarian hormone stimulation and ovum pick up. 3) Women who need medication which opposes the efficacy of tamoxifen (e.g. fluotexine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is the serum endoxifen level during the whole period of ovarian hyperstimulation. The endoxifen level is a binary outcome measure, a level | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline characteristics, ovarian hyperstimulation, the resulting number and quality of embryos and oocytes frozen. Data with regard to the cycle day, hour of tamoxifen intake and the hour of blood sample and follicle-fluid collections for measurement of active tamoxifen-metabolites are collected as well. | — |
Countries
Netherlands
Outcome results
None listed