Circadian rhythms of glucose metabolism, adipose gene expression and coagulation in type 2 diabetes

Circadian rhythms of glucose metabolism, adipose gene expression and coagulation in type 2 diabetes - RHYTHM

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON35845

Enrollment

Registered

2011-07-22

Start date

2012-02-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes metabolic syndrome

Interventions

Subjects will take isocaloric meal replacement by standard liquid meal replacement (Ensure, Abbott industries) divided into three identical meals at fixed timepoints.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: Male, type 2 diabetes, Age 30-75 yr, BMI 25-40 kg/m2 Controls: Male, Age 30-75 yr , BMI

Exclusion criteria

Exclusion criteria: Patients: Use of any other anti-diabetic drug than metformin Acute or chronic metabolic disease (other than type 2 diabetes) that will impair metabolism or digestion and absorption of food, including gastro-intestinal, hepatic or renal disease Inability to give informed consent Shift work in the month before intervention Crossing several timezones in the month before intervention;Controls Any acute or chronic metabolic disease that will impair metabolism or digestion and absorption of food, including gastro-intestinal, hepatic or renal disease Inability to give informed consent Shift work in the month before intervention Crossing several timezones in the month before intervention

Design outcomes

Primary

Measure	Time frame
Difference between patients and controls in circadian glucose excursions, hemostasis, and gene expression profiles in adipose tissue.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)