The Prevalence and Genotype of Genital (High-Risk) Human Papillomavirus Infections in Female Renal Transplant Recipients

The Prevalence and Genotype of Genital (High-Risk) Human Papillomavirus Infections in Female Renal Transplant Recipients - (hr)HPV-infection prevalence and genotype in female RTRs

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35840

Enrollment

500

Registered

2011-10-07

Start date

2012-02-29

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervico-vaginal HPV infection Human papillomavirus infection of the cervix

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Female sex • Received a renal transplantation at the RUNMC in the period 1968 - 2008 • Age >= 18 years at start of the study

Exclusion criteria

Exclusion criteria: • Patients not willing to sign and/or return the informed consent form • Patient is pregnant, or within a period of 3 months after delivery • Patient is within a period of 3 months after miscarriage

Design outcomes

Primary

Measure	Time frame
The main study parameters are the prevalence of HPV infections and the distribution of different HPV genotypes in our immunocompromised cohort.	—

Secondary

Measure	Time frame
Secondary endpoints are the prevalence of abnormal PAP smears and of cervical pathology as diagnosed by gynaecological examination and colposcopy. Other study parameters: Population characteristics (sociodemographic features, medical data and information regarding sexual behaviour) and experiences of the self-sampling will be evaluated as well. Moreover, we will compare sociodemographic and medical data of the non-responders (i.e. age, marital status and duration of immunosuppression which will retrospectively be collected from the medical charts of these patients) with corresponding data of the responders.	—

Measure

Time frame

Secondary endpoints are the prevalence of abnormal PAP smears and of cervical pathology as diagnosed by gynaecological examination and colposcopy. Other study parameters: Population characteristics (sociodemographic features, medical data and information regarding sexual behaviour) and experiences of the self-sampling will be evaluated as well. Moreover, we will compare sociodemographic and medical data of the non-responders (i.e. age, marital status and duration of immunosuppression which will retrospectively be collected from the medical charts of these patients) with corresponding data of the responders.

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Countries

Netherlands

Outcome results