vochthuishouding dehydration fluid deficiency
Conditions
Interventions
None listed
Sponsors
Slotervaartziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: a. Adults >= 18 years old. b. Able to provide informed consent. c. Diagnosis of central diabetes insipidus (DI). (only for patients)
Exclusion criteria
Exclusion criteria: a. Strong suspection of an infection of any cause b. Primary polydipsia and diabetes insipidus (for the healthy volunteers). c. Untreated thyroid and adrenal hormone abnormalities. d. Pregnancy or puerperium. e. Common etiologies of the syndrome of inappropriate antidiuretic hormone (SIADH); Active malignancy, inflammatory diseases (multiple sclerosis, meningitis, systemic lupus erythematosus), acquired immuno- deficiency syndrome (AIDS), infections (tuberculosis, pneumonia, empyema) (only for those 6 patients without signs of infection), cystic fibrosis, drugs (Selective serotonine reuptake inhibitors, tricyclic antidepressants, carbamazepine, clofibrate, narcotics, antipsychotic drugs, cytotoxic drugs) f. Potentiation of AVP antidiuretic effects: desmopressin, vasopressin, oxytocin, prostaglandin synthesis inhibitors
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| urine osmolality, plasma osmolality, antidiuretic hormone, hematocrit. | — |
Primary
| Measure | Time frame |
|---|---|
| Coagulation and fibrinolysis activation markers: F1+2 (fragment 1+2), ETP (endogenous thrombin potential), D-dimer, Plasminogen Activator Inhibitor-1 (PAI-1) activity. Endothelial cell activation and platelet activation markers: von Willebrand factor activity (vWf:C), clotting factor VIII activity (fVIII:C). Blood coagulation time: PT. | — |
Countries
Netherlands
Outcome results
None listed