The ART-NECO study;Long term effective combination antiretroviral therapy (cART) and its effect on neurocognition. A prospective cohort study to assess the feasibility of two short cognitive screen tests in patients infected with HIV1 and the development of neurocognitive impairment over time

The ART-NECO study;Long term effective combination antiretroviral therapy (cART) and its effect on neurocognition. A prospective cohort study to assess the feasibility of two short cognitive screen tests in patients infected with HIV1 and the development of neurocognitive impairment over time - Art NeCo

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35825

Enrollment

100

Registered

2012-01-05

Start date

2012-01-16

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuro-HIV

Interventions

Neuropsychological test MRI cerebrum Lumbar puncture(s) Blood punctures

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * HIV-seropositive 18-65 years (Western Blot) * Treatment with cART * HIVRNA in plasma

Exclusion criteria

Exclusion criteria: * Active opportunistic infection * Active psychiatric disorder for which treatment is indicated * Overt cognitive disorder due to other co morbidity (e.g. of vascular origin) * Malignancy * Established neurosyphilis * Drug addiction * Excessive (> 2 U/d) use of alcohol

Design outcomes

Primary

Measure	Time frame
- the incidence of cognitive deficits in a Dutch cohort of HIV1 seropositive patients on chronic cART; - the utility, the sensitivity and specificity of a short cognitive screening test (the MoCA) in detecting HAND, and the International Aids Dementia scale in comparison with extensive neuropsychological tests	—

Secondary

Measure	Time frame
- The course of cognitive function in HIV infection over one year - the detection of brainabnormalities visualized by MRI - to establish the relation between HIV-associated neurocognitive disorders and quality of life, subjective well-being and subjective cognitive complaints.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)