Brain MR imaging in paroxysmal kinesigenic dyskinesia

Brain MR imaging in paroxysmal kinesigenic dyskinesia - MRI of the brains in PKD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35798

Enrollment

Registered

2011-09-01

Start date

2011-09-06

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brief and frequent sudden attacks of involuntary movements

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Diagnosis of PKD by a neurologist and clinical geneticist according the clinical criteria of Bruno et al (2004); - Age: 16 years and older. - Informed consent - Able to lay still for a prolonged time (about an hour);

Exclusion criteria

Exclusion criteria: - Secondarily caused PKD symptoms; - Contra-indications for MRI scanning; - Neurocognitive disorders related to brain abnormalities or psychiatric disease.

Design outcomes

Primary

Measure	Time frame
The study purpose is to objectify activation patterns in basal ganglia and cortical sensorimotor areas in PKD affected individuals and in healthy normal controls. Outcome measures: - Structural imaging: grey and white matter volumes (mm³); - Diffusion tensor imaging: mean diffusity (MD) and fractional anisotropy (FA); - Functional imaging: number of significantly (Pcorrected	—

Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results