cardiovascular disease
Conditions
Interventions
Five single doses of a cocoa products in randomised order with a minimal 5-day
interval. Four of those cocoa products contain a high level of flavenols and
are commercially available. One product is
Sponsors
Callebaut NV
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Adults between 20 and 45 years old -Non*smoking individuals -Capable and willing to sign the Informed Consent Form at voluntary basis -Considered healthy based on their medical history as questioned by the investigator during an interview and a general physical examination by the investigator -Female volunteers do not intend to become pregnant prior to or during the study and using adequate contraception
Exclusion criteria
Exclusion criteria: -Clinically significant abnormal liver biochemistry -Clinically significant abnormal serum creatinin -Abnormal body mass index -Use of concomitant medications or supplements -Blood donation during the last 4 weeks prior to the first dosing till 4 weeks after the last dosing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the blood concetration - time curve (AUC). | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximal blood concentration (Cmax) and time to maximal blood concentration (Tmax). | — |
Countries
Netherlands
Outcome results
None listed