Q-fever post-vaccination study

Q-fever post-vaccination study - Q-fever post-vaccination study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35763

Enrollment

400

Registered

2011-05-24

Start date

2011-08-31

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coxiella burnetii infection Q-fever

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Signed Informed Consent - willing to adhere to blood draw schedule - has taken part in the national Q-fever vaccination campaign

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Humoral immune response: IgG and IgM antibodies against fase 1 and 2 antigens of C. burnetii are measured by means of several serological tests:: immune fluorescence assay (IFA), enzyme-linked immuno sorbent assay (ELISA), complement binding reaction (CBR), polymerase chain reaction (PCR) and micro-array. Cellular immune response: After stimulation of whole blood, the levels of interferon-gamma (IFN-gamma), interleukine (IL)-10 and possibly IL-12 production are measured. Also a T-helper 1 and T-helper 2 cytokine profile are measured in isolated mononuclear cells, isolated CD14+ monocytes and isolated T-cells after stimulation, and differentiation of the cells is studied.	—

Measure

Time frame

Humoral immune response: IgG and IgM antibodies against fase 1 and 2 antigens of C. burnetii are measured by means of several serological tests:: immune fluorescence assay (IFA), enzyme-linked immuno sorbent assay (ELISA), complement binding reaction (CBR), polymerase chain reaction (PCR) and micro-array. Cellular immune response: After stimulation of whole blood, the levels of interferon-gamma (IFN-gamma), interleukine (IL)-10 and possibly IL-12 production are measured. Also a T-helper 1 and T-helper 2 cytokine profile are measured in isolated mononuclear cells, isolated CD14+ monocytes and isolated T-cells after stimulation, and differentiation of the cells is studied.

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Countries

Netherlands

Outcome results