Impairments and complaints during activities of daily living in patients with mild COPD.

Impairments and complaints during activities of daily living in patients with mild COPD. - Impairments during ADL in mild COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35698

Enrollment

125

Registered

2011-11-15

Start date

2011-11-30

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic airflow limitation chronic obstructive pulmonary disease (COPD)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: Clinically stable COPD patients with GOLD stage I (= mild COPD, a FEV1/VC ratio (forced expiratory volume in one second divided by the vital capacity) = 80% of predicted) and >=18 years old. Controls: Subjects with normal lung function and with similar ages and gender distribution as the patients with COPD.

Exclusion criteria

Exclusion criteria: Patients: patients with long term oxygen therapy at home, with co-existing lung disease other than COPD (including asthma), with restrictive lung function, with other exercise-limiting disorders than COPD like cardiac or neuromuscular disease, or patients using β-blockers are excluded from the study. Controls: subjects with abnormal lung function or history of lung disease, with exercise-limiting disorders like cardiac or neuromuscular disease, or using β-blockers are excluded from the study.

Design outcomes

Primary

Measure	Time frame
For the first objective, the main study parameter is dynamic hyperinflation during ADL in patients with mild COPD and in controls. For the second objective, the main study parameter is the difference in dynamic hyperinflation during ADL in patients and controls after a two-year interval.	—

Secondary

Measure	Time frame
During ADL: Ventilatory parameters: ventilation (Ve), breathing reserve (BR), Ve/maximal ventilatory capacity (MVC), ventilatory equivalent for CO2 (Ve/VCO2), partial pressure of end-tidal CO2 (PetCO2), breathing frequency (BF). Operational lung volumes: inspiratory reserve volume (IRV), tidal volume (Vt) Cardiovascular parameters: heart rate (HR), HR reserve, O2-pulse, blood pressure Other: oxygen consumption (VO2), dyspnea, ADL-time, gas exchange	—

Measure

Time frame

During ADL: Ventilatory parameters: ventilation (Ve), breathing reserve (BR), Ve/maximal ventilatory capacity (MVC), ventilatory equivalent for CO2 (Ve/VCO2), partial pressure of end-tidal CO2 (PetCO2), breathing frequency (BF). Operational lung volumes: inspiratory reserve volume (IRV), tidal volume (Vt) Cardiovascular parameters: heart rate (HR), HR reserve, O2-pulse, blood pressure Other: oxygen consumption (VO2), dyspnea, ADL-time, gas exchange

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Countries

Netherlands

Outcome results