Study on the effects of sodium and potassium on blood pressure, vascular function and renal function in untreated (pre)hypertensive subjects

Study on the effects of sodium and potassium on blood pressure, vascular function and renal function in untreated (pre)hypertensive subjects - KaNa-trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON35685

Enrollment

Registered

2011-12-21

Start date

2012-03-12

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nierfunctie (estimated glomerular filtration rate) elevated blood pressure vascular funtion

Interventions

One-week run-in period, followed by 3 periods of 4 weeks intervention. During the run-in period and intervention periods the subjects will remain on a low-sodium, low-potassium diet, which provides

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Systolic Blood Pressure between 130-159 No use of cardiovascular medication Age 40 years and over

Exclusion criteria

Exclusion criteria: Chronic diseases (as diabetes, cardiovascular diseases, renal impairment)

Design outcomes

Primary

Measure	Time frame
The primary parameters is flow-mediated dilation (FMD).	—

Secondary

Measure	Time frame
Secondary parameters involve: diastolic blood pressure (DBP), centrale blood pressure, 24-hour ambulatory blood pressure, augmentation index (Aix), pulse wave velocity (PWV), vasomotion, estimated glomerular filtration rate (eGFR) and plasma biomarkers of endothelial function and low-grade inflammation, as asymmetric dimethylarginine (ADMA), endothelin-1, nitric oxides (NOx), monocyte chemoattractant protein (MCP-1), soluble endothelin selection (sE-selectin), soluble-thrombomodulin (sTM), von Willebrand factor (vWF), the cell adhesion molecules sVCAM-1 and sICAM-1, C-reactive protein (CRP), serum amyloid A (SAA), interleukin 6 (IL-6), interleukin 8 (IL-8) and tumor necrosis factor-a (TNF-a)	—

Measure

Time frame

Secondary parameters involve: diastolic blood pressure (DBP), centrale blood pressure, 24-hour ambulatory blood pressure, augmentation index (Aix), pulse wave velocity (PWV), vasomotion, estimated glomerular filtration rate (eGFR) and plasma biomarkers of endothelial function and low-grade inflammation, as asymmetric dimethylarginine (ADMA), endothelin-1, nitric oxides (NOx), monocyte chemoattractant protein (MCP-1), soluble endothelin selection (sE-selectin), soluble-thrombomodulin (sTM), von Willebrand factor (vWF), the cell adhesion molecules sVCAM-1 and sICAM-1, C-reactive protein (CRP), serum amyloid A (SAA), interleukin 6 (IL-6), interleukin 8 (IL-8) and tumor necrosis factor-a (TNF-a)

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)