exercise induced asthma exercise induced bronchoconstriction
Conditions
Interventions
No intervention, other than the exercise provocation challenge, will be
investigated. An exercise provocation challenge is part of the routine clinical
evaluation of patients with exercise induced s
Sponsors
Medisch Spectrum Twente
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: - Clinical history of asthma symptoms. - Age 5-7 years. - Ability to perform reproducible lung function tests, i.e. coefficient of the predicted value variation in 3 of 5 consecutive measurements
Exclusion criteria
Exclusion criteria: - Use of systemic corticosteroids in the last 4 weeks prior to the study. - Use of long acting bronchodilators 24 hours before testing. - Use of short acting bronchodilators 8 hours before testing. - Use of leukotriene antagonists 24 hours before testing. - Other pulmonary or cardiac disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main objective of this study is the measurement of pulmonary function (change in FEV1, FEV0.5 and FEF50) during and post-exercise in young children with asthmatic features. Thus the percent change in pulmonary function (FEV1, FEV0.5 and FEF50) during and post-exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are: -analysis of anthropometric measures, clinical features, medication use and history (measured by extensive history) of children with a positive or negative exercise provocation challenge. -analysis of the feasibility of a newly designed exercise provocation challenge using a jumping castle. | — |
Countries
Netherlands
Outcome results
None listed