The effect of cold acclimation on human brown adipose tissue and skeletal muscle uncoupling

The effect of cold acclimation on human brown adipose tissue and skeletal muscle uncoupling - Role of cold acclimation on human brown adipose tissue

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON35672

Enrollment

Registered

2011-10-19

Start date

2011-12-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

geen nvt

Interventions

Cold exposure. For 10 consecutive days the subjects will be exposed to cold (12 C). To easily get used to this, exposure will be 2hours at the 1st day, 4hours at the 2nd day and day 3-10 6hours/day.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy lean (BMI 18-25) adults Age: 18-30 years Females: on 1 oral contraceptive (Microgynon 30 / levonorgestrel/ehinylestradiol) Caucasians

Exclusion criteria

Exclusion criteria: Diabetes mellitus Females: pregnancy Participate in physical activity more than 2x/week Use of Beta-blockers Cardiovascular diseases Asthma or other obstructive pulmonary diseases Elevated fasting blood glucose level (> 5.6 mmol/L) Participation in earlier research that included a PET/CT-scan Radiation therapy due to medical treatment

Design outcomes

Primary

Measure	Time frame
Standard uptake values (SUV's) of FDG of active brown adipose tissue Energy expenditure Skeletal muscle mitochondrial uncoupling BRITE cell recruitment	—

Secondary

Measure	Time frame
Body temperatures (core and skin temperatures) Skin perfusion Body composition Blood parameters	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)