bicuspid aortic valve
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients are included in this study with severe aortic stenosis and planned surgical aortic valve replacement when they*re at least 18 years old and not fitting any of the exclusion criteria. Written informed consent.
Exclusion criteria
Exclusion criteria: Patients with concomitant heart disease: previous myocardial infarction, endocarditis, patients with prior aortic valve replacement and aortic insufficiency. Patients younger than 18 years of age are also excluded from participation in this study. Patients who have a syndromic or genetic diagnosis, for example, Marfan*s disease, trisomy 21 and Turner*s syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identifying gene variations/mutations in patients with a bicuspid aortic valve and severe aortic stenosis, who will undergo aortic valve replacement therapy. Occurrence of gene variations/mutations in a cohort of patients with a stenotic aortic valve. | — |
Secondary
| Measure | Time frame |
|---|---|
| Characterize the nature and effect of any mutations identified. | — |
Countries
Netherlands
Outcome results
None listed