RAAS-blockade in type II diabetes: added effects of a low sodium diet and diuretics.

RAAS-blockade in type II diabetes: added effects of a low sodium diet and diuretics. - DiNaMO

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON35646

Enrollment

Registered

2008-04-11

Start date

2008-05-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes Type II diabetes

Interventions

Study includes two interventions: Patients will be randomized to low and high sodium intake in a cross-over design Patients will be randomized to 25 mg hydrochlorothiazide or placobo

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age between 18-70 years Type II diabetes Albuminuria > 30 mg/24h Stable 24h creatinine clearance >30 ml/min/1,73 m2

Exclusion criteria

Exclusion criteria: Contraindication for the use of lisinopril or hydrochlorothiazide Type I diabetes Myocardial infarction or stroke within 3 month prior to the research Kidneydisease unrelated to diabetes or hypertension Proteinuria >3 gr/24h Hypertension unresponsive to therapy during run-in period Inabilty for informed consent Incompliance to diet or studymedication Inaccordance with inclusioncriteria Pregnancy

Design outcomes

Primary

Measure	Time frame
Response of urinary albumin excretion to hydrochlorothiazide and a low sodium diet during the different interventions.	—

Secondary

Measure	Time frame
Blood pressure response, renal function response en response of extracellular.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)