Graves' disease
Conditions
Interventions
None listed
Sponsors
Oogziekenhuis Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: General inclusion criteria: - age >= 18 years - written informed consent;Graves* patients: - hyperthyroid - raised free thyroxin (fT4) level - decreased TSH level - diffuse non-nodular appearance of thyroid on palpation, scan or ultrasonography - positivity for TSH-receptor antibodies (Brahms Diagnostics, Berlin, Germany);Contrast AT patients: - clinically hypothyroid - lowered serum fT4 level - raised TSH level - positive for TPO antibodies - negative for TSH-receptor antibodies (Brahms Diagnostics, Berlin, Germany);Healthy individuals: - self-proclaimed good health - free of any obvious medical illness for at least two weeks prior to the blood withdrawal, including acute infections and allergic reactions - no medication (apart from anti-conceptive hormonal therapy)
Exclusion criteria
Exclusion criteria: The exclusion criteria for all subjects in the study are: any immune disorder other than thyroid autoimmunity, serious other medical illness, recent infections (last 2 weeks), fever, pregnancy/postpartum for 6 months, obvious vascular complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Production of IL-16 by orbital fibroblast in culture after stimulation with patient IgG. | — |
Secondary
| Measure | Time frame |
|---|---|
| Production of RANTES, hyaluronan and the proliferation level of orbital fibroblasts in culture after stimulation with patient IgG. | — |
Countries
Netherlands
Outcome results
None listed