The Genetic variability in the host response to community-acquired pneumonia

The Genetic variability in the host response to community-acquired pneumonia - Genetic risk of pneumonia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35629

Enrollment

2000

Registered

2009-05-12

Start date

2009-12-09

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lower respiratory tract infection pneumonia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1.Age of 18 years of older 2.Admission to the hospital 3.Community-acquired pneumonia defined as: a.New or progressive infiltrate on a chest X-ray and b.2 of the following criteria: -Cough -sputum production -dyspnea -rectal temperature > 38oC or 10.000/mm3, or >15% bands) -C-reactive protein > 3 times the upper limit of normal 4. A least three grandparents form Dutch origin

Exclusion criteria

Exclusion criteria: 1.Hospitalization for more than >=48h in the 2 weeks prior to enrollment in the study 2.Infections other than pneumonia that need immediate treatment 3.Life expectancy

Design outcomes

Primary

Measure	Time frame
1.To identify genetics variations associated with the genetic risk of susceptibility to community-acquired pneumonia.	—

Secondary

Measure	Time frame
1.To identify genetic variations associated with a severe community-acquired pneumonia on admission. Pneumonia severity will be determined by (a) mortality of community-acquired pneumonia within 24 hours; (b) Pneumonia severity scores: Pneumonia Severity Index and CURB-65 score (appendix 4) and (c) Location of treatment after first survey in ER (ward versus ICU). 2.To indentify genetic variations associated with poor response to treatment: determined by (a) development of complications during hospitalization (b) mortality after first day and within 30 days of admission. (c) admission to ICU during hospitalization.	—

Measure

Time frame

1.To identify genetic variations associated with a severe community-acquired pneumonia on admission. Pneumonia severity will be determined by (a) mortality of community-acquired pneumonia within 24 hours; (b) Pneumonia severity scores: Pneumonia Severity Index and CURB-65 score (appendix 4) and (c) Location of treatment after first survey in ER (ward versus ICU). 2.To indentify genetic variations associated with poor response to treatment: determined by (a) development of complications during hospitalization (b) mortality after first day and within 30 days of admission. (c) admission to ICU during hospitalization.

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Countries

Netherlands

Outcome results