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Intervention induced reconfiguration of functional brain networks in dyslexic readers

Intervention induced reconfiguration of functional brain networks in dyslexic readers - Developmental dyslexia, intervention and the adaptive brain

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON35622
Enrollment
45
Registered
2012-03-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

specific learning disability Developmental dyslexia wordblindness

Interventions

None listed

Sponsors

Radboud Universiteit Nijmegen
Lead Sponsor

Eligibility

Age
2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Diagnosed with developmental dyslexia by a professional accredited institute and on a waiting list to start intervention at a professional accredited institute. (i.e. following criteria set by the Dutch Ministry of Health, 2nd of July, 2008 that would include coverage by basic public health insurance)

Exclusion criteria

Exclusion criteria: Other learning disabilities, comorbidity with ADHD, Dyscalculia (i.e. following criteria set by the Dutch Ministry of Health, 2nd of July, 2008 that would exclude coverage by basic public health insurance);Exclusie criteria gerelateerd aan metingen met een MRI en MEG scanner.

Design outcomes

Primary

MeasureTime frame
1. Measures derived from complex network analysis, spectral analysis of different frequency bands, and recurrence quantification analysis are generally expected to converge on: - less scale-free organization in dyslexic readers' brain networks when compared to average reading peers. - deviations from 1/f noise (f.i. towards white noise or Brownian noise) in the time series of dyslexic readers' brain activity when compared to average reading peers. - more random or laminar attractor dynamics of the functional network of dyslexic readers when compared to average reading peers. 2. The expected organization characteristics sketched in 1 are hypothesized to be present most clearly in the tasks that require most integration of component processes. 3. Within-subject analyses over the three measurement occasions are expected to reveal more scale-free organization in those participants who benefit from the intervention. Moreover, for those participants the observation of scale-free organization is expected to increase in tasks that require highest level of integration of component processes.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)