Small fibre neuropathy in critical illness

Small fibre neuropathy in critical illness - SENSS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35607

Enrollment

Registered

2011-11-28

Start date

2012-01-03

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intensive Care Unit - acquired weakness

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: diagnosed with Intensive Care Unit - acquired weakness available in het AMC for investigation 25 days after ICU admission

Exclusion criteria

Exclusion criteria: risk factor for small fibre neuropathy bleeding disorder delayed wound healing leukopenia

Design outcomes

Primary

Measure	Time frame
- the difference in intra-epidermal nerve fibre density measured using bright field immunohistochemistry between patients with ICU-AW and normative values matched for age and gender known in the literature	—

Secondary

Measure	Time frame
- correlation between muscle strength and IENF density - correlation between clinical markers (e.g sensory disturbances) for small nerve fibre function and IENF density - correlation between temperature discrimination threshold and IENF density - deposition of various inflammatory markers using immunohistochemistry - density of post ganglionic sympathetic fibres	—

Countries

Netherlands

Outcome results