GERD heartburn
Conditions
Interventions
stop medication for 1 week
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: GERD patients with good symptom response to PPI: - Written informed consent - 18-75 years - PPI use of 1-2 daily 40 mg of Omeprazole, Esomeprazole or pantoprazole, or 1-2 daily 30 mg of lansoprazole. - GERD confirmed by pH-impedance (ph 4,5 % of time or positive symptom association), or in patients with reflux esophagitis.;GERD patients with bad symptom response to PPI: - Written informed consent - 18-65 years - PPI use of 1-2 daily 40 mg of Omeprazole, Esomeprazole or pantoprazole, or 1-2 daily 30 mg of lansoprazole. - GERD confirmed by pH-impedance during medication, with a positive symptom association between reflux episodes and symptoms (Symptom Index >50%, or a Symptom Association Probability >95%).
Exclusion criteria
Exclusion criteria: - surgery of the gastrointestinal tract other then appendectomy - inability to stop the use of proton pump inhibitors for one week - participation in another study with exposure to radiation within the last year - long segment of Barrett*s epithelium
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study outcome: - The position of the postprandial gastric acid pocket relative to the esophagogastric junction | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study outcomes: - Esophageal sensitivity for distension and chemical stimuli (VAS scores) - Concentration of Bile acids in the gastric acid pocket - The rate of postprandial acid reflux events - The size of the postprandial acid pocket - The acidity of postprandial reflux events - The acidity of the postprandial gastric acid pocket - Histology of the esophageal mucosa - Permeability of the esophageal mucosa | — |
Countries
Netherlands
Outcome results
None listed