freezing of gait Parkinson's Disease
Conditions
Interventions
The intervention used in this study is Theta Burst Stimulation (TBS), which is
a repetitive form of Transcranial Magnetic Stimulation. In total four
stimulions will be given seperated over four diff
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Idiopathic Parkinson's Disease patients diagnosed according to the UK Brain Bank criteria. - Hoehn and Yahr stage 2 or 3. - Presence of freezing of gait.
Exclusion criteria
Exclusion criteria: - Presence of neurological disease other than Parkinson's Disease. - Presence of deep brain stimulator. - MMSE score under 24 - Contra indications for administrating TMS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome for this study is the total time a patient freezes during the gait and upper limb task. This outcome will be rated by a blinded examinator who rates the videos of the different tasks off-line. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The stride length (amplitude) and velocity in the gait task. 2. The amplitude and velocity of the flexion-extension movement of the index fingers in the upper limb task. 3. The average duration and the frequency of freezing in the gait and the upper limb task. 4. MEP amplitude before and after TBS stimulation. 5. The performance on the pegboard test. | — |
Countries
Netherlands
Outcome results
None listed