Is it really mitochondrial Pi? A study into the origin of the alkaline inorganic phosphate signal as observed by 31P MRS at 7T

Is it really mitochondrial Pi? A study into the origin of the alkaline inorganic phosphate signal as observed by 31P MRS at 7T - Using MRS to rule out blood origination of Pi signal

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35595

Enrollment

Registered

2011-10-10

Start date

2011-10-17

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy controls

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy adult volunteers

Exclusion criteria

Exclusion criteria: - Claustrophobia - Pacemakers and defibrillators - Nerve stimulators - Intracranial clips - Intraorbital or intraocular metallic fragments - Cochlear implants - Ferromagnetic implants (e.g. thoracic implant for scoliosis) - any muscle disease - recent muscle trauma

Design outcomes

Primary

Measure	Time frame
Peak intensity of the putative mitochondrial inorganic phosphate signal will be investigated, both before and during inflation of the cuff. In addition, the relative increase in the size of the leg as well as the blood vessels will be calculated, to obtain a measure for the expected increase in blood volume in the leg.	—

Countries

Netherlands

Outcome results