geen specifieke aandoening door het gebruik van microarrays nvt
Conditions
Interventions
Two intervention periods of eight weeks with an one of the two isoflavone
supplements and a placebo for each subject and a washout period of 8 weeks in
between.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: women 50-70 year postmenopausal
Exclusion criteria
Exclusion criteria: - current use of contraceptives containing hormones - current use of hormone replacement therapy - regular soy product use (more than once a week) - regular isoflavone supplement use (more than once a week) - current use of medication containing sexhormones or sexhormone-triggering compounds - current use of anti-inflammatory medicines - use of antibiotics in the past 3 months - severe heart disease - diabetes - thyroid disorders --> use of medicines for thyroid disorders - removed thyroid gland - complete ovarectomy - prior diagnosis of cancer in medical history - alcohol and drug abuse - current smoker - BMI >35 kg/m2 - allergy to soy (products)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is gene-expresion in PBMCs measured by micro-arrays | — |
Secondary
| Measure | Time frame |
|---|---|
| Isoflavone levels in plasma Gene - expression measured by micro-arrays in adipose tissue Isoflavone levels in adipose tissue. | — |
Countries
Netherlands
Outcome results
None listed