Head and neck paraganglioma pheochromocytoma tumor of the adrenal medulla
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. 18 years of age or older 2. Patients with diagnosed or clinically suspected PGLs and/or pheochromocytomas. a. Diagnosis of pheochromocytoma and sympathetic PGL (golden standard): i. Histology postoperative or; ii. Hypertension and; iii. Elevated plasma and/or urinary (nor)metanephrines and; iv. Localization of pheochromocytoma with anatomical imaging (computed tomography (CT)/ Magnetic Resonance Imaging (MRI)) and functional imaging including ¹²³I- metaiodobenzylguanidin (MIBG) scintigraphy or 18F- dihydroxyphenylalanine (DOPA) positron emission tomography (PET). b. Diagnosis of a HNPGL (golden standard): i. Postoperative histology or; ii. Clinical symptoms and; iii. Localization of a HNPGL with anatomical imaging (CT/MRI) and nuclear imaging including ¹¹¹-In-octreotide/ ¹²³I-MIBG scintigraphy or DOPA-PET. c. Suspected PGL: i. Patients with a proven SDH-mutation
Exclusion criteria
Exclusion criteria: 1.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity of platelet levels of dopamine in platelets rich plasma in patients with HNPGL compared to the defined golden standard | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity (and specificity) in patients with suspected PGL and pheochromocytoma compared to the golden standard | — |
Countries
Netherlands
Outcome results
None listed