preterm infants very low birth weight infants
Conditions
Interventions
The intervention group 1 will receive lipids from birth onwards. Intervention
group 2 will receive extra amino acids in combination with lipids from birth
onwards. The control group will be fed acco
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Born within the Sophia Children's Hospital Birth weight less than 1500g Written informed consent
Exclusion criteria
Exclusion criteria: Congenital anomalies Metabolic disease Endocrine, renal or hepatic disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nitrogen balance | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety of the nutritional regimen: as reflected by normal blood chemistry, no effect on hearing ability, no effect on chronic lung disease Growth: measured in terms of body weight, protein accretion and protein breakdown Fatty acid profile in plasma and erythrocytes, plasma phytosterol profile Energy expenditure Short- and long-term outcome: days on mechanical ventilation, incidence of bronchopulmonary dysplasia, incidence of infection, incidence of intraventricular hemorrhage, incidence of necrotizing enterocolitis, normal ALGO (screening for hearing loss), brain growth and development at 30 and 40 and/or 46 weeks gestational age and Bayley III scores (Mental Developmental Index and Psychomotor Developmental Index) at 2 years of age (corrected age for gestational age). | — |
Countries
Netherlands
Outcome results
None listed