anesthesie autoregulation disturbances Diabetic neuropathy
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age between 18*75 years Scheduled for non-cardiac intermediate or high risk surgery Informed consent For patient group 2a: indication for thoracic epidural anesthesia For patient group 2b: undergoing robot assisted thoracic sympathectomy
Exclusion criteria
Exclusion criteria: Known/documented cardiac disease (Untreated) hypertension Abnormal ECG or echocardiogram Peripheral vascular disease Renal disease requiring hemo- or peritoneal dialysis Inability to perform transthoracic echocardiography Medication interfering with presynaptic catecholamine uptake For patient group 2: contra-indication for thoracic epidural anesthesia (bleeding diasthesis, infection at the puncture site, patient refusal, severe stenotic valvular disease) Previous allergic reaction to echocardiographic contrast agents Contraindication for use of echocardiographic contrast agent Pregnancy Intracranial neurosurgery Sympathectomy Vascular surgery including carotidsurgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in coronary blood flow in the absence or presence of sympathetic stimulation during sevoflurane anesthesia in patients with and without cardiovascular sympathetic innervation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical signs of cardiovascular autonomic neuropathy with cardiovascular reflex tests and heart rate variability. | — |
Countries
Netherlands
Outcome results
None listed