Immune paralysis in trauma patients: an explorative study

Immune paralysis in trauma patients: an explorative study - Immune paralysis in trauma patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35513

Enrollment

Registered

2011-12-07

Start date

2011-10-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune paralysis impaired function of the immune system following trauma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients admitted to the UMC St Radboud with trauma

Exclusion criteria

Exclusion criteria: Age below 18, expected clinical risks of blood sampling, known HIV/AIDS, conditions known to influence the immune response (e.g. auto-immune diseases), use of medication known to influence the immune response (e.g. steroids)

Design outcomes

Primary

Measure	Time frame
Cytokine production following ex vivo whole blood stimulation to identify immune paralysis.	—

Secondary

Measure	Time frame
Plasma mtDNA concentrations, mRNA expression levels of genes known to be involved in immune paralysis, other DAMP concentrations in plasma, infections, blood gas values, vital parameters, age, body mass index, trauma mechanism, Injury Severity Score (ISS), use of medication, surgical interventions.	—

Countries

Netherlands

Outcome results