constipation defecation disorder
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the indexpatients: - Patients diagnosed with functional constipation not responding to maximal conservative treatment (laxatives, enemas, bowel cleansing) for at least 6 months prior to sacral neuromodulation (SNM) therapy, but responding to SNM therapy. -Patients aged 12-18 years at time of the implantation of the sacral neuromodulator.;Inclusion Criteria for parents of indexpatients: -Fathers and mothers of indexpatients.;Informed consent is needed for all individuals to be included. Informed consent will also be asked for by the parents as participating children will be aged 12 to 18 years.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the indexpatients - Patients suffering from organic pathology causing constipation. -Patients with a history of large bowel surgery, congenital anorectal malformations or neurological disease. -Patients not able to read and understand the written information. ;Exclusion criteria for the parents of indexpatients -Individuals not able to read and understand the written information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the identification of genes associated with childhood refractory constipation. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome will consist of a thorough description of the clinical characteristics, the phenotype, of children with refractory constipation responding to sacral neuromodulation therapy. | — |
Countries
Netherlands
Outcome results
None listed