Adverse life events and mental symptoms
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: Children under treatment: i) need to be between 12 and 17 years old;Siblings: i) need to be at least 12 years of age (no upper age limit); ii) at least one sibling needs to participate (if available) and iii) more than one sibling is allowed to participate (if available).;Parents of controls: i) need to be the biological parent; ii) participation is preferred, however not needed for cases and their siblings to be included into the study and iii) more than one parent is allowed to participate.;Controls: i) need to be between 12 and 17 years old.;Parents of controls: i) need to be the biological parent; ii) participation is preferred, however not needed for controls to be included into the study and iii) more than one parent is allowed to participate.
Exclusion criteria
Exclusion criteria: For all participants: When a participant (child and/ or parent) does not want to be informed about any possible clinically relevant findings that can be found throughout the study. ;Cases: i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language; iii) being diagnosed with an Autistic Spectrum Disorder according to the DSM-IV with the exception of Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and iv) being adopted. ;Siblings: i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language; iii) being diagnosed with an Autistic Spectrum Disorder according to the DSM-IV with the exception of PDD-NOS and iv) being adopted.;Parents of cases: i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language.;Controls: i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language; iii) being diagnosed with an Autistic Spectrum Disorder according to the DSM-IV with the exception of PDD-NOS; iv) being adopted and v) in the presence of a lifetime history of treatment at a mental health care institution. ;Parents of controls: i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main parameter is current psychopathology (defined as (1) psychotic symptoms, (2) depressive symptoms, and (3) symptoms of anxiety) as well as the development of psychopathology within a timeframe of 2 years, depending on exposure to traumatic experiences. | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify the mechanisms by which trauma leads to psychopathology a. stress sensitivity b. family situation (e.g. attachment) c. molecular genetic variation d. social cognition | — |
Countries
Netherlands
Outcome results
None listed