ernstig zieke kinderen met verschillende aandoeningen nvt
Conditions
Interventions
One group will first get the lower amount of glucose infusion followed by the
higher amount. The other group will first get the higher amount of glucose
infusion followed by the lower amount.
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Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: -critically ill patients after elective surgery ( cardial, craniofacial of scoliosis surgery) admitted to the ICU -critically ill patients with various medical diseases and > 1 organ failure admitted to the ICU. - with arterial line -inclusion 1 to 12 hours after admission -cardiorespiratory stable -only parental glucose after admission
Exclusion criteria
Exclusion criteria: endocrine disorders, liver failure, chromosomal disorders, insulin therapy no arterial line of after removal arterial line no informed consent in case of patient after elective cardiac surgery: no extracorporal circulation during cardiac surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -endogenous glucose production -fractional gluconeogenesis -glucose utilization -whole body protein balance. - fractional albumin synthesis rate. | — |
Secondary
| Measure | Time frame |
|---|---|
| indirect calorimetry:determination of total energy expenditure urine samples for nitrogen excretion: protein utilization anthropometry | — |
Countries
Netherlands
Outcome results
None listed