Serum allergens and innate lymphoid cells in eosinophilic esophagitis.

Serum allergens and innate lymphoid cells in eosinophilic esophagitis. - Serum allergens and ILCs in EoE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35461

Enrollment

Registered

2011-11-14

Start date

2011-10-07

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(idiopathic) eosinophilic esophagitis Allergic esophagitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid-esophageal biopsies * Written informed consent * Age 18 * 75 years

Exclusion criteria

Exclusion criteria: * History of peptic ulcer disease * History of Barrett*s esophagus * History of GI cancer * History of GI tract surgery (except appendectomy) * ASA class IV or V

Design outcomes

Secondary

Measure	Time frame
- The number of ILC2 cells in periferal blood of adult EoE patients. - Biomarkers for disease activity of eosinophilic esophagitis before and after 8 weeks of standard PPI treatment.	—

Primary

Measure	Time frame
- IgE reactivity to recombinant allergens of common foods and inhalants in adult EoE patients.	—

Countries

Netherlands

Outcome results