Optimization of Cardiac Resynchronization Therapy at rest and during exercise conditions.

Optimization of Cardiac Resynchronization Therapy at rest and during exercise conditions. - OPTI-CARE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35451

Enrollment

Registered

2008-08-19

Start date

2008-11-05

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure ventricular dyssynchrony

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Indication for Cardiac Resynchronization Therapy according to the current international guidelines. (See research protocol: chapter 5.2)

Exclusion criteria

Exclusion criteria: Criteria for the complete study: (see also research protocol chapter 5.3) -Contraindications for implantation of a CRT device; -Age 100 bpm); -Baseline heart rate 180 mmHg or

Design outcomes

Primary

Measure	Time frame
The difference, in milliseconds, between the optimal AVD/VVD during resting conditions versus exercise.	—

Secondary

Measure	Time frame
To reach the secondary objectives, the following parameters are also measured: the intrinsic atrio- and interventricular conduction times on the intracardiac electrogram; coronary sinus dP/dt; a matrix with the dP/dt for all possible combinations of AVDs and VVDs. Moreover echocardiographic indices of mechanical asynchrony during rest and dobutamine infusion are determined.	—

Countries

Netherlands

Outcome results