liver resection partial chirugical removal of the liver
Conditions
Interventions
An intervention is only applicable to study group 3-5, healthy volunteers,
receiving a low dose of 2 gram APAP (4*0.5 gram APAP over 24 hours).
In study group 1 and 2, the administration of 4 grams
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For liver / pancreas resection patients: •All patients undergoing a non laparoscopic liver or pancreas resection. •Age above 18 years For healthy volunteers: •Age match to liver / colon resection group
Exclusion criteria
Exclusion criteria: •Alcohol abuse up to 6 months before participation in this research. •Aberrations or insufficiency of kidney, liver, gut, heart or longs apart from the disease to be treated. •Presence of persistent inflammation in the gut or liver. •Use of drug known to affect the liver metabolism. •Endocrine or metabolic aberrations. •Anaemia or infection. •HIV infection or hepatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are changes in gene expression profile and metabolomic profile measured after and caused by APAP exposure. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed