Maintaining health in old age through homeostasis

Maintaining health in old age through homeostasis - Switchbox

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35448

Enrollment

120

Registered

2011-10-19

Start date

2012-05-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

betreft gezonde proefpersonen zonder aandoening healthy ageing longevity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Couples from the Leiden Longevity Studie, consisting of a child from a longlived family (case) and his/her current partner (control)

Exclusion criteria

Exclusion criteria: Endocrin problems: diabetes, thyroid and adrenal problems MRI: metal (parts) in the body and claustrofobia

Design outcomes

Primary

Measure	Time frame
Offspring/Partner Neuro-endocrine output characterization via: 24 hours hormone rhythm measurement (ACTH, TSH, fT4, fT3, cortisol, insulin, glucose, adiponectin) Offspring/Partner Peripheral metabolism characterization via: Glucose sampling using continuous glucose monitor Indirect calorimetry using ventilated hood Core body temperature Diet and activity monitoring using diaries and accelerometry Physical activity measurement using tri-axial accelerometer Characterization of Brain functions in Offspring/Partners, via: * Functional MRI studies in stressed and non-stressed condition o Reaction times on the Working Memory (WM) task - Offspring (Stress > no stress) no stress) - Brain activation during emotional WM task performance: (associated with impaired task performance) o Amygdala functional connectivity: - Controls (Stress > no stress) > Offspring (Stress > no stress) o Dorsolateral Prefrontal Cortex: Stress no stress We expect offspring to show smaller stress effects on the reciprocal relation between dorsal and ventral brain activation compared to controls. * Cognition and mood (test batteries) * Sleep (via diaries and accelorometry)	—

Measure

Time frame

Offspring/Partner Neuro-endocrine output characterization via: 24 hours hormone rhythm measurement (ACTH, TSH, fT4, fT3, cortisol, insulin, glucose, adiponectin) Offspring/Partner Peripheral metabolism characterization via: Glucose sampling using continuous glucose monitor Indirect calorimetry using ventilated hood Core body temperature Diet and activity monitoring using diaries and accelerometry Physical activity measurement using tri-axial accelerometer Characterization of Brain functions in Offspring/Partners, via: * Functional MRI studies in stressed and non-stressed condition o Reaction times on the Working Memory (WM) task - Offspring (Stress > no stress) no stress) - Brain activation during emotional WM task performance: (associated with impaired task performance) o Amygdala functional connectivity: - Controls (Stress > no stress) > Offspring (Stress > no stress) o Dorsolateral Prefrontal Cortex: Stress no stress We expect offspring to show smaller stress effects on the reciprocal relation between dorsal and ventral brain activation compared to controls. * Cognition and mood (test batteries) * Sleep (via diaries and accelorometry)

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Countries

Netherlands

Outcome results