Differences in gene expression profile between Glucocorticoid-responsive and Glucocorticoid-nonresponsive patients with rheumatoid arthritis

Differences in gene expression profile between Glucocorticoid-responsive and Glucocorticoid-nonresponsive patients with rheumatoid arthritis - Gene expression of Glucocorticoid response in RA patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35438

Enrollment

Registered

2009-05-19

Start date

2009-07-30

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rheumatism rheumatoid arthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Clinical indication for Glucocorticoid therapy either in high dose (Cohort A) or low dose (Cohort B) based on the judgement of the treating/attending physician according to clinical practice in our outpatient clinic.

Exclusion criteria

Exclusion criteria: 1) Clinical contrandications for GC-therapy as handled in our outpatient clinic 2) Change of (DMARD) medication in the last month 3) GC treatment in the last month in both cohorts.

Design outcomes

Primary

Measure	Time frame
A list of markers seen in monocytes and T cells that are differently expressed in GC-responders versus GC nonresponders.	—

Secondary

Measure	Time frame
A list of markers seen in monocytes and T cells that are differently expressed in patients experiencing side effects and patients without side effects.	—

Countries

Netherlands

Outcome results