Idiopathic non-cirrhotic intrahepatic portal hypertension (INCIPH): assessment of thrombophilia and histopathology in a multicentre cohort study and HIV patients.

Idiopathic non-cirrhotic intrahepatic portal hypertension (INCIPH): assessment of thrombophilia and histopathology in a multicentre cohort study and HIV patients. - Idiopathic non-cirrhotic intrahepatic portal hypertension (INCIPH)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON35427

Enrollment

Registered

2009-04-22

Start date

2009-11-24

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatoportal sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) Evidence of portal hypertension (oesophageal varices, hypersplenism or ascites) 2) Doppler ultrasound showing patent portal and hepatic veins 3) Liver biopsy showing no cirrhosis 4) Exclusion of conditions causing cirrhosis according to conventional diagnostic criteria (chronic viral hepatitis, alcoholic liver disease, NASH, obesity, hemochromatosis, autoimmune hepatitis or Wilson*s disease) 5) Exclusion of chronic vitam A intake, professional exposure to copper sulphate, vinyl chloride monomer, Spanish toxic oil or arsenic salts 6) Older than 18 years at diagnosis. 7) HIV patients

Exclusion criteria

Exclusion criteria: 1) Presence of cirrhosis 2) Presence of portal thrombosis at diagnosis 3) Presence of conditions causing cirrhosis according to conventional diagnostic criteria (chronic viral hepatitis, alcoholic liver disease, NASH, obesity, hemochromatosis, autoimmune hepatitis or Wilson*s disease). 4) Presence of chronic vitam A intake, professional exposure to copper sulphate, vinyl chloride monomer, Spanish toxic oil or arsenic salts 5) Younger than 18 years old at diagnosis. 6) intake oral anticoagulation

Design outcomes

Primary

Measure	Time frame
Prevalence of thrombophilic factors. Clinical evolution. Pathologic features Fibroscan and ultrasound elements. Presence of INCIPH in HIV patients	—

Countries

Netherlands

Outcome results